Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18669L |
(S,R,S)-AHPC-Me-C10-NH2 hydrochloride
(S,R,S)-AHPC-Me-C10-NH2盐酸盐 |
Ligand for E3 Ligase | PROTAC |
(S,R,S)-AHPC-Me-C10-NH2 hydrochloride 是一种合成的 E3 连接酶配体-接头偶联物,包含 VHL 配体和接头。 | |||
T13671 |
(S,R,S)-AHPC-Me hydrochloride
VHL ligand 2 hydrochloride,E3 ligase Ligand 1 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein. |