Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2063 |
Tyrphostin 23
RG-50810,TX 825,Tyrphostin A23,AG18 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tyrphostin 23 (AG18) 是一种EGFR 抑制剂,IC50值为35 μM。 | |||
T21128 |
Lansoprazole sulfide
Lansoprazole impurity C,AG-1777,EC 600-451-9,H 225/18,K-1252 |
||
Lansoprazole sulfide is an impurity of Lansoprazole, which is a gastric pump inhibitor. | |||
T69196 |
AG-012986
|
||
AG-012986 is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 showed antiproliferative activities in vitro with IC(50)s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 was seen (tumor growth inhibition, >83.1%) in 10 of 11 human xenograft tumor models. AG-012986 also showed dose-dependent retinoblastoma Ser(795) hy... | |||
T69197 |
AG-012986 HCl
|
||
AG-012986 HCl is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 HCl showed antiproliferative activities in vitro with IC(50)s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 HCl was seen (tumor growth inhibition, >83.1%) in 10 of 11 human xenograft tumor models. AG-012986 HCl also showed dose-dependent retinoblas... |