Cat. No. | Product Name | Target | Signaling Pathways |
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T62274 |
AChE/BChE-IN-2
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AChE/BChE-IN-2 (Compound 13b) 是一种 AChE/BChE 的有效抑制剂,对 AChE 和 BChE 的 IC50 值分别为 0.96 ± 0.14 μM 和 1.23 ± 0.23 μM。AChE/BChE-IN-2 对 AD 疾病表现出研究潜力。 | |||
T72452 |
AChE/BChE/MAO-B-IN-2
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AChE/BChE/MAO-B-IN-2 是一种有效的 AChE、BChE 和 MAO-B 酶抑制剂,IC50值分别为 48.2 nM、83.9 nM 和 31.2 nM。AChE/BChE/MAO-B-IN-2 具有显着的抗氧化活性,可用于帕金森病的研究。 | |||
T60691 |
AChE/BChE/BACE-1-IN-2
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AChE/BChE/BACE-1-IN-2 (Compound 4o) 表现出显著的抗氧化潜力和对PAS-AChE 的强大的结合能力。AChE/BChE/BACE-1-IN-2 是口服有效的AChE、BACE-1和BChE 抑制剂,对 hAChE、hBACE-1 和hBChE 的IC50分别为 0.069、0.097 和0.127 μM。AChE/BChE/BACE-1-IN-2 显示出对潜在的 Aβ 聚集物的分解能力和针对 Aβ 诱导的应激的神经保护作用。 | |||
T63215 |
COX-2-IN-22
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COX-2-IN-22 是一种能够透过血脑屏障的 COX-2 抑制剂 (IC50: 8.6 μM),也对AChE (IC50: 2.8 μM)、BChE (IC50: 6.3 μM)、β-Secretase (IC50: 15.3 μM)、LOX-5 (IC50: 13.9 μM) 和 DPPH (IC50: 6.8 μM)表现出抑制作用。 | |||
T38005 |
P11149
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P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer’s disease[1]. P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG[1].P11149 exhibits greater s.c. bioavailability than p.o. [1].Oral P11149 in mice pr... | |||
T77235 | Methylene Violet 3RAX | ||
Methylene Violet 3RAX 是一种吩嗪染料,用于染色细胞的线粒体。Methylene Violet 3RAX 可以改变DNA 的分子结构,破坏DNA 的模块,诱导活性单线态氧的产生。Methylene Violet 3RAX 对人红细胞AChE 和人血浆BChE 具有抑制作用,Kis 分别为 1.58 和 0.51 μM。Methylene Violet 3RAX 具有研究PDT (光动力疗法) 中线粒体靶向作用的潜在光敏剂的潜力。 | |||
T36639 | Donecopride (fumarate hydrate) | ||
Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= 3,530 nM) but does bind to 5-HT2Band sigma-2 (σ2) receptors (Ki= 1.6 nM for both) in a panel of 42 neurotransmitter receptors and transporters. Donecopride induces release of soluble amyloid precursor protein-α (sAPP-α) in COS-7 cells transiently expressing 5-HT4with an EC50value... |