Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6750 |
Opaganib
ABC294640 |
S1P Receptor | GPCR/G Protein |
Opaganib (ABC294640) 是选择性和竞争性的鞘氨醇激酶 2 (SK2) 抑制剂,Ki 为 9.8 μM。 | |||
T71299 |
M-25
|
||
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway. | |||
T71301 | Opaganib HCl | ||
ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis a... |