Cat. No. | Product Name | Target | Signaling Pathways |
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T60828 |
AAK1-IN-2
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AAK1-IN-2 (compound (S)-31) 可用于神经性疼痛的研究,它是衔接蛋白 2 相关激酶 1 (AAK1)的选择性抑制剂 (IC50 = 5.8 nM),具有脑渗透性。 | |||
T63833 | AAK1-IN-2 TFA | ||
AAK1-IN-2 TFA (compound (S)-31) 是一种选择性的、有效的、能够透过血脑屏障的 AAK1 抑制剂 (IC50: 5.8 nM)。AAK1-IN-2 TFA 能够用于研究神经性疼痛。 | |||
T35856 |
BMS-986176
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AAK1 (AP2 associated kinase 1) | Neuroscience |
BMS-986176 是一种有效的AAK1 抑制剂,IC50为 2.2 nM。BMS-986176在神经退行性疾病中有研究的价值。 | |||
T63834 | AAK1-IN-3 TFA | ||
AAK1-IN-3 TFA 是一种能够透过血脑屏障的适配蛋白 2 相关激酶 1 (AAK1) 抑制剂 (IC50: 11 nM),是一种喹啉类似物。AAK1-IN-3 对神经病理性疼痛表现出研究潜力。 | |||
T60829 |
AAK1-IN-3
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AAK1-IN-3 是一种喹啉类似物,可用于研究神经病理性疼痛。AAK1-IN-3 是衔接蛋白 2 相关激酶 1 (AAK1) 抑制剂,IC50为 11 nM,具有脑渗透性。 | |||
T61693 |
AAK1-IN-5
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AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivity, with an AAK1 inhibitory potency (IC 50) of 1.2 nM, a binding affinity (K i) of 0.05 nM, and an inhibitory potency against cellular AAK1 activity (cell IC 50) of 0.5 nM. AAK1-IN-5 holds promise for investigating neuropathic pain in scientific research [1]. | |||
T61499 |
AAK1-IN-4
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AAK1-IN-4 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), capable of efficiently penetrating the central nervous system and exhibiting oral bioactivity. It has demonstrated a high degree of selectivity with an AAK1 inhibitory concentration (IC50) of 4.6 nM, a Filt dissociation constant (Ki) of 0.9 nM, and a cellular IC50 of 8.6 nM. AAK1-IN-4 holds promise as a valuable tool in the investigation of neuropathic pain [1]. | |||
T61941 |
BMT-090605 hydrochloride
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BMT-090605 hydrochloride 是有效的,选择性的连接蛋白-2 相关激酶 1(AAK1)抑制剂,(IC50=0.6 nM)。BMT-090605 hydrochloride 抑制 BMP-2 诱导蛋白激酶 (BIKE) (IC50=45 nM)和细胞周期蛋白 G 相关激酶 GAK(IC50=60 nM)。BMT-090605 hydrochloride 显示抗伤害活性。BMT-090605 hydrochloride 在神经性疼痛中具有研究价值。 | |||
T62143 | LP-922761 hydrate | ||
LP-922761 hydrate 是一种选择性的、有效的、口服具有活力的 AAK1 抑制剂,在酶和细胞分析中 IC50 值分别为 4.8 nM 和 7.6 nM。LP-922761 hydrate 对 BMP-2 诱导蛋白激酶 (BIKE) 具有抑制作用 (IC50: 24 nM)。LP-922761 hydrate 对细胞 GAK、阿片类药物、肾上腺素 α2 或 GABAa 受体没有明显作用。 |