Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8513 |
Spastazoline
|
Others | Others |
Spastazoline 是spastin(一种微管切断AAA 蛋白) 的选择性抑制剂,对人 spastin 的IC50值为 99 nM。它不能影响重组人 VPS4 的 ATPase 活性。 | |||
T5425 |
ML367
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
ML367 是一种稳定的、有效的 ATPase 家族 AAA 结构域蛋白 5 抑制剂,是一个探针分子,具有低摩尔抑制浓度。它可以阻断 DNA 的修复通路,抑制一般的 DNA 损伤反应,包括应对紫外照射产生的 RPA32 和 CHK1 的磷酸化。 | |||
T9008 |
NPD8733
|
Others | Others |
NPD8733 是癌细胞增强的成纤维细胞迁移抑制剂。它是与多种细胞活动 (AAA+) 蛋白家族相关的 ATP 酶的成员,能够与含 valosin 的蛋白 (VCP)/p97特异性结合,对癌症疾病具有潜在的研究价值。 | |||
T27165 |
Diazaborine
Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474 |
||
Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of the protein from the nucleolus to t | |||
T35855 |
AAA
|
||
AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension... |