Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37792 |
A2A receptor antagonist 1
CPI-444 analog,A2A receptor antagonist 1 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
A2A receptor antagonist 1 (CPI-444 analog)是腺苷 A2A 和 A1受体的拮抗剂,Ki 值分别为4和264 nM。 | |||
T22031 |
ANR 94
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
ANR94 是一种有效的、选择性的腺苷 A2A 受体 (AA2AR) 拮抗剂,对 hAA2AR 的Ki 值为 46 nM。ANR94 具有用于帕金森病的研究潜力。 | |||
T37014 | Inupadenant | ||
Inupadenant is an orally active, highly selective A2A receptor antagonist. Inupadenant is not brain-penetrant. Inupadenant has potent anti-tumor activity[1]. [1]. Laurence Buisseret, et al. Phase 1 trial of the adenosine A2Areceptor antagonist inupadenant (EOS-850): Update on tolerability, and antitumor activity potentially associated with the expression of the A2A receptor within the tumor. Journal of Clinical Oncology. Volume 39, Issue 15_suppl. | |||
T62611 |
Adenosine receptor antagonist 2
|
||
Adenosine receptor antagonist 2 是一种具有口服活性的 A2a (IC50: 1 nM) /A2b (IC50: 3 nM) 腺苷受体拮抗剂。Adenosine receptor antagonist 2 表现出抗肿瘤效果。 | |||
T60591 |
A2AAR antagonist 1
|
||
A2AAR antagonist 1 (compound 21a) 是A2AAR(腺苷A2A 受体) 的拮抗剂,具有高配体效率,Ki 值为 20 nM。A2AAR antagonist 1 可用于神经退行性疾病的相关研究。 | |||
T74606 | A2A/A3 AR antagonist-1 | ||
A2A/A3 AR antagonist-1 (化合物 23) 是一种双重 A2A/A3adenosine receptor(AR)荧光配体,对 hA2AAR 和 hA3AR 的 Ki 值分别为 90 nM 和 31.8 nM。 | |||
T61850 |
Adenosine receptor inhibitor 1
|
||
Adenosine receptor inhibitor 1 is a highly potent and selective antagonist of adenosine receptor (AR). It exhibits exceptional affinity for A1 AR, A2A AR, A2B AR, and A3 AR, with respective Ki values of >1000, 68.5, >1000, >1000 nM. This compound demonstrates notable antinociceptive, anti-inflammatory, and peripheral analgesic properties. Therefore, Adenosine receptor inhibitor 1 holds great promise for investigating cancer and neurodegenerative diseases [1]. | |||
T72626 |
A2AR-antagonist-1
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
A2AR-antagonist-1 (compound 38) 为一种口服活性的腺苷 A2A 受体 (A2AR) 拮抗剂,IC50 值为 29 nM。此化合物展示出抗肿瘤作用,并在小鼠肝微粒体中表现出良好的代谢稳定性,半衰期为 86.1 分钟。同时,A2AR-antagonist-1 能够作为 T 细胞激活剂,通过抑制免疫抑制分子 LAG-3 和 TIM-3,以及增强 GZMB、IFNG 和 IL-2 等效应分子的表达。 | |||
T70770 |
Cyclazosin Free Base
|
||
Cyclazosin Free Base is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of furoic acid with the secondary amino group of 6,7-dimethoxy-2-[(4aR,8aS)-octahydroquinoxalin-1-yl]quinazolin-4-amine. It has a role as an adenosine A2A receptor antagonist. It is a member of quinazolines, a member of furans, an aromatic ether, a quinoxaline derivative, an aromatic amide and a monocarboxylic acid amide. |