19
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19717 |
Cyclo-L-Trp-L-Trp
|
Antifungal | Microbiology/Virology |
Cyclo-L-Trp-L-Trp 是一种广谱抗真菌剂。它还诱导组蛋白的高度乙酰化。 | |||
T1569 |
Tigecycline
替加环素,GAR-936 |
ribosome; Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Tigecycline (GAR-936) 是甘氨酰环素抗生素,对 Acinetobacter baumannii(A. baumannii) 的 MIC50和 MIC90分别为 1 和 2 mg/L。它对 E. coli(MG1655 菌株) 的平均抑制浓度 (MIC) 约 125 ng/ mL。 | |||
T11125 |
Durlobactam sodium salt
杜巴坦,ETX2514 sodium salt,杜洛巴坦 |
Antibacterial | Microbiology/Virology |
Durlobactam sodium salt (ETX2514 sodium salt)是一种 β-内酰胺酶抑制剂,针对 A 类 KPC-2、C 类 AmpC 和 D 类 OXA-24,IC50 值分别为 4 nM、14 nM 和 190 nM。 Durlobactam sodium salt 可用于对包括鲍曼不动杆菌在内的耐药革兰氏阴性菌的研究。 | |||
T70429 |
TP-6076
|
||
TP-6076 is a fluorocycline antibiotic, inhibiting bacterial protein synthesis, exhibiting great antimicrobial activity against carbapenem-resistant A. baumannii. | |||
T75279 | Tigecycline tetramesylate | ||
Tigecycline tetramesylate (GAR-936 tetramesylate)为一款广谱甘氨酰环素类抗生素,对E. coli (MG1655菌株)展现出约125 ng/mL的平均抑制浓度(MIC)。针对Acinetobacter baumannii (A. baumannii)的MIC50与MIC90分别达到1 mg/L与2 mg/L。 | |||
T68438 |
APO-6619
|
||
APO-6619 is an iron chelator which was shown to inhibit growth of the following bacterial strains: Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. APO-6619 may be useful as a non-traditional treatment of bacterial infections. | |||
T27211 |
DS-8587
DS 8587,DS8587,DS-8587 free |
||
DS-8587 is a DNA topoisomerase inhibitor. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. DS-8587 significantly reduces the number of viabl | |||
T80372 |
P1
|
||
P1是一种具有抗革兰氏阳性菌与抗革兰氏阴性菌能力的广谱抗菌肽,有效针对B. anthracis、耐碳青霉烯类细菌A. baumannii和K. pneumoniae。 | |||
T39983 |
SPR206 acetate
|
||
SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetate effectively combats bacterial infections. Notably, SPR206 acetate demonstrates significant efficacy with minimum inhibitory concentration (MIC) values of 0.125 mg/L against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301. | |||
T83758 |
SAAP 148 TFA
Synthetic Antimicrobial and Antibiofilm Peptide 148 |
||
SAAP 148是一种抗菌肽。在体外,它对多种耐多药的细菌有活性。在体内,SAAP 148(0.125-2% w/w)能减少小鼠A. baumannii或耐甲氧西林金黄色葡萄球菌(MRSA)感染模型中皮肤菌落形成单位(CFUs)的数量。 | |||
T83689 |
Histatin 8 TFA
Hst-8 |
||
Histatin 8是一种唾液抗微生物肽,是histatin 3和histatin 5的蛋白水解片段。针对A. baumannii(包括对colistin敏感或耐药的菌株)在32 µg/ml浓度下显示活性。Histatin 8也对C. albicans和C. tropicalis显示活性(MICs分别为1和5 mg/ml)。 | |||
T74866 | Antibacterial agent 116 | ||
Antibacterial agent 116 是一种含二苯甲酮的水杨酰苯胺类化合物。Antibacterial agent 116 能抑制肽聚糖的形成而具有较强的抗菌活性。Antibacterial agent 116 可作为光亲和探针标记 Acinetobacter baumannii 的青霉素结合蛋白 (PBP1b),干扰肽聚糖链的生长,阻断其增殖。 | |||
T39296 |
DS86760016
|
||
DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively. | |||
T78673 |
Antibacterial agent 135
|
||
Antibacterialagent 135(示例7)是一种针对多种细菌具有抑制作用的有效抗菌剂,包括铜绿假单胞菌、鲍曼不动杆菌、大肠杆菌和肺炎克雷伯菌,其最小抑菌浓度(MIC)大于64 μg/mL。 | |||
T70798 |
Benastatin B
|
||
Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; Ki = 3.7 µM for the rat liver enzyme).2 Benastatin B also inhibits the transglycosylase activity of A. baumannii, C. difficile, E. coli, and S. aureus recombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 µM, respectively).3 It is active against several bacteria, including methicillin-resistant S.... | |||
T79240 |
DNA gyrase B-IN-2
|
||
DNA gyrase B-IN-2 (Compound E) 是一款基于2-aminobenzothiazole的DNA gyrase B抑制剂,针对ESKAPE病原体显示出强效活性。该化合物在低纳摩尔浓度下表现出优异的DNA gyrase B抑制能力(IC50< 10 nM),具备对多种ESKAPE病原体的广谱抗菌作用。对于大部分革兰氏阳性菌,最低抑菌浓度(MIC)低于0.03 μg/mL;针对革兰氏阴性病原体如E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa和Klebsiella pneumoniae,MIC为4 - 16 μg/mL。此化合物适用于感染性疾病的研究应用。 | |||
T73798 |
Colistin
|
||
Colistin (Polymyxin E) 是一种具有口服活性的多肽类抗生素。它对包括多重耐药铜绿假单胞菌、鲍曼不动杆菌和肺炎克雷伯菌在内的多种革兰氏阴性杆菌表现出良好的抑制作用。此外,Colistin 与肾毒性相关,常用于研究革兰氏阴性菌感染。 | |||
T23459 |
Tigecycline hydrochloride
|
Others | Others |
Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms. | |||
T23460 |
Tigecycline mesylate
|
Others | Others |
Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83903 |
Polymyxin B2 sulfate
|
||
Polymyxin B2是一种抗生素,并且是从B. polymyxa分离出的阳离子脂肽抗生素polymyxin B的主要成分。该化合物对P. aeruginosa、A. baumannii、K. pneumoniae和E. cloacae菌株具有活性(MICs分别为1-2、0.5-1、0.25-0.5和0.25-1 µg/ml)。在体内实验中,以4 mg/kg剂量的Polymyxin B2能显著降低P. aeruginosa血液感染小鼠模型中的血液集落形成单位(CFUs)数量。 |