Cat. No. | Product Name | Target | Signaling Pathways |
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T36890 |
A 410099.1
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High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells. Oost et al (2004) Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem. 47 4417 PMID:15317454 |Loeder et al (2009) A n... | |||
T39081 |
A 410099.1, amine-Boc
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A-410099.1, also known as amine-Boc, serves as a functionalized IAP ligand instrumental in the synthesis of PROTACs, including those targeting BTK (specifically PROTACs 4 and 5). | |||
T68578 |
A-410099.1 free base
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A-410099.1 is a novel potent xiap antagonist | |||
T35471 |
A 410099.1 amide-PEG3-amine
A 410099.1 amide-PEG3-amine |
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Functionalized IAP ligand for PROTAC research and development; incorporates an IAP ligand plus a short amide-PEG linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T35473 |
A 410099.1 amide-PEG5-amine
A 410099.1 amide-PEG5-amine |
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Functionalized IAP ligand for PROTAC research and development; incorporates an IAP ligand plus an amide-PEG5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T35472 |
A 410099.1 amide-PEG4-amine
A 410099.1 amide-PEG4-amine |
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Functionalized IAP ligand for PROTAC research and development; incorporates an IAP ligand plus an amide-PEG4 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T35470 |
A 410099.1 amide-PEG2-amine
A 410099.1 amide-PEG2-amine |
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Functionalized IAP ligand for PROTAC research and development; incorporates an IAP ligand plus a short amide-PEG linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T35469 |
A 410099.1 amide-alkylC4-amine
A 410099.1 amide-alkylC4-amine |
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Functionalized IAP ligand for PROTAC research and development; incorporates an IAP ligand plus an amide-alkylC4 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T39919 |
A 410099.1, amine-Boc hydrochloride
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A 410099.1, amine-Boc hydrochloride, serves as a functionalized IAP (Inhibitor of Apoptosis Proteins) ligand instrumental in the synthesis of PROTACs (Proteolysis Targeting Chimeras), notably those targeting BTK (Bruton's Tyrosine Kinase), including PROTACs 4 and 5. | |||
T40052 |
A 410099.1 amide-PEG2-amine-Boc
A 410099.1 amide-PEG2-amine-Boc |
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A 410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand for PROTACs, consisting of an IAP ligand and an amide-PEG3 linker with a terminal amine. It is capable of forming conjugates with target protein ligands. | |||
T40053 |
Boc-A 410099.1 amide-alkylC4-amine
Boc-A 410099.1 amide-alkylC4-amine |
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Boc-A 410099.1 amide-alkylC4-amine is a functionalized IAP ligand for PROTACs, comprising of an IAP ligand and an amide-alkylC4 linker terminating in an amine group. It has the ability to form conjugates with target protein ligands. | |||
T40054 |
A 410099.1 amide-PEG3-amine-Boc
A 410099.1 amide-PEG3-amine-Boc |
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A 410099.1 amide-PEG3-amine-Boc is an IAP ligand-based functionalized molecule commonly used in PROTACs. It comprises an IAP ligand and an amide-PEG3 linker that possesses a terminal amine. The compound can successfully conjugate with target protein ligands. |