Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11837 |
Leptomycin A
|
CRM1 | Membrane transporter/Ion channel |
Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the interaction between CRM1 and nuclear export signals, effectively hindering the nuclear export of a wide array of proteins. |