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Cat. No. Product Name Target Signaling Pathways
T37155 8(R)-HETE

8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T37772 tetranor-12(R)-HETE

Metabolism of 12(R)-HETE in corneal tissue produces predominantly the compound resulting from the loss of four carbon atoms through β-oxidation from C-1. This metabolite is 8(R)-hydroxy hexadecatrienoic acid (8(R)-HHxTrE) or 2,3,4,5-tetranor 12(R)-HETE.
T37156 8(S),15(S)-DiHETE

8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. It causes eosinophil chemotaxis with an ED50 value of 1.5 μM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes the hyperalgesic activity of 8(R),15(S)-DiHETE and LTB4 in the rat hind paw pain model.

化合物

8(R)-HETE
Cat.No: T37155
Synonym:
Target:
tetranor-12(R)-HETE
Cat.No: T37772
Synonym:
Target:
8(S),15(S)-DiHETE
Cat.No: T37156
Synonym:
Target:
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