Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79802 |
5-HT2C agonist-3
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT2C agonist-3 ((+)-19)为高选择性5-HT2C激动剂,其EC50为24 nM,Ki值为78 nM。该化合物表现出抗精神病药物样的活性,并能有效抑制安非他明诱导的多动症。 | |||
T79803 |
5-HT2C agonist-3 free base
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT2C agonist-3 ((+)-19) free base 是选择性的5-HT2C激动剂,具EC50: 24 nM及Ki: 78 nM值。该化合物展现出抗精神病药物样活性,并能阻断安非他明引起的多动症。 | |||
T50011 |
(2-methylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amine
|
Others | Others |
(2-methylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amine 是一种选择性血清素受体激动剂,特异性靶向5-HT2A 和5-HT2C 受体,已被用于研究血清素在各种生理和病理条件下的作用。 | |||
T50039 |
3-(2-aminopropyl)phenol hydrochloride
|
Others | Others |
3-(2-aminopropyl)phenol hydrochloride 是一种用作分子结构单元的苯乙胺类化合物。它是一种精神活性药物,是5-HT1A、5-HT1B 和5-HT2C 等几种血清素受体的部分激动剂,也是5-HT2A 受体的拮抗剂。 | |||
T82891 |
Bexicaserin
|
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Bexicaserin (Compound 3)为5-HT2C受体激动剂,可研究治疗肥胖及精神疾病。 | |||
T10192 |
7-Desmethyl-3-hydroxyagomelatine
3-Hydroxy-7-desmethyl agomelatine |
5-HT Receptor | GPCR/G Protein; Neuroscience |
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist. | |||
T79155 |
5-HT2A receptor agonist-3
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT2A receptor agonist-3,具有当前已知的最高选择性,是针对人类5-HT2A receptor的激动剂,其Ki值仅为2.5 nM。该化合物相较于结构类似的5-HT2A receptor激动剂,其对5-HT2A的选择性高达124倍。 | |||
T38145 | Eltoprazine | ||
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no... | |||
T83776 |
Dopamine D3 Receptor Agonist 13a
|
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Dopamine D3 受体激动剂13a是一种Dopamine D3 受体激动剂。该化合物选择性地与Dopamine D3 受体结合,相较于Dopamine D1、D2和D4受体(Kis = 0.14、4,600、2.85和756 nM,分别)具有更高的亲和力,并且还能与血清素(5-HT)受体亚型5-HT1A、5-HT2A、5-HT2B和5-HT2C(Kis = 6、54、1.47和252 nM,分别)结合;然而,它是Dopamine D2受体的部分激动剂(EC50 = 2.26 nM,在G蛋白招募分析中)并且作为Dopamine D3受体的拮抗剂(IC50 = 4.62 nM)。在大鼠身上,当剂量为3 mg/kg时,Dopamine D3 受体激动剂13a能减少可卡因自我给药。 |