Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10169 |
5-HT4 antagonist 1
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5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT4 antagonist 1 是 5-HT4 的拮抗剂 (pKi = 9.6)。 | |||
T61381 |
Loxapine hydrochloride
|
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Loxapine hydrochloride is a dibenzoxazepine anti-psychotic agent that exerts its effects through oral administration, functioning as an inhibitor of dopamine and an antagonist of 5-HT receptors [1] [4]. | |||
T83909 |
6-hydroxy Buspirone
BMY 28674,BMS-52821 |
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6-hydroxy Buspirone是抗焦虑化合物buspirone的活性代谢产物,通过细胞色素P450(CYP)亚型CYP3A4从buspirone转化而来。该化合物在大鼠海马和背侧缝核的5-羟色胺(5-HT)受体亚型5-HT1A上具有亲和力(EC50s分别为4和1 µM),并作为多巴胺D2、D3、D4受体拮抗剂(IC50s分别为3.1、4.9、和0.85 µM)。同时,它还以浓度依赖性方式抑制表达人类转运体的S2近端小管细胞中的有机阳离子转运体1(OCT1)、OCT2和OCT3。 | |||
T38145 | Eltoprazine | ||
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no... |