Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6755 |
AM1241
|
Cannabinoid Receptor | GPCR/G Protein |
AM1241 是一种选择性大麻素 CB2 受体激动剂,Ki 为 3.4 nM,比 CB1 受体选择性高 82 倍。 | |||
T38147 |
(S)-AM1241
(S)-AM1241 |
||
(S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors). (S)-1241 acts as an agonist at human, rat, and mouse CB2 receptors but shows greater activity at human CB2 (EC50 = 131 nM) than at rat and mouse CB2 receptors (EC50 = 785 and 2,000 nM, respectively). Similar to the racemate AM1241 , (S)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. Th... | |||
T38030 |
(R)-AM1241
(R)-AM1241 |
||
(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing... |