Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36008 |
Nebentan potassium
YM598 |
Endothelin Receptor | GPCR/G Protein |
Nebentan potassium (YM598) 是一种具有口服活性和选择性的非肽类内皮素受体 (ETA receptor) 拮抗剂。Nebentan potassium 抑制肺动脉高压,可用于研究神经系统疾病和心血管疾病。 | |||
T36007 |
Nebentan
|
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Nebentan (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2]. Nebentan inhibits the specific binding of [125I] endothelin-1 to endothelin ETA and ETB receptors in a concentration dep... |