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Cat. No.	Product Name	Target	Signaling Pathways
T60152	AZ5576	CDK	Cell Cycle/Checkpoint
	AZ5576 是一种有效且高选择性的 CDK9抑制剂。AZ5576 可用于血液恶性肿瘤研究。
T70953	AZ5576 racemate
	AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage a...