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Cat. No. Product Name Target Signaling Pathways
T11441 GNE-987

Epigenetic Reader Domain Chromatin/Epigenetic
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and 4.4 nM, respectively). GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50: 0.03
T12798 (S)-GNE-987

Epigenetic Reader Domain Chromatin/Epigenetic
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).

化合物

GNE-987
Cat.No: T11441
Synonym:
Target: Epigenetic Reader Domain
(S)-GNE-987
Cat.No: T12798
Synonym:
Target: Epigenetic Reader Domain
TargetMol Loading
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