Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16667 |
PROTAC Sirt2 Degrader-1
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1]. |