Cat. No. | Product Name | Target | Signaling Pathways |
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T63038 |
WAY-181187 oxalate
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WAY-181187 (SAX-187) oxalate 是一种选择性的、有效的 5-HT6 受体的激动剂 (Ki: 2.2 nM; EC50: 6.6 nM)。WAY-181187 oxalate 是一种特异性激动剂,介导 5-HT6 受体依赖性信号通路(如 cAMP,Fyn 和 ERK1/2 激酶)。 | |||
T69104 |
SAX-187 hydrochloride
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SAX-187 hydrochloride is a potent and selective 5-HT6 receptor agonist. SAX-187 hydrochloride possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (SAX-187 hydrochloride: EC50=6.6 nM, Emax=93%). In the rat frontal cortex, acute administration of SAX-187 hydrochloride (3-30 mg/kg, subcutaneous (s.c.)) significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine. | |||
T3183 |
SAX-187
WAY 181187,WAY181187 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
SAX-187 (SAX-187) 是一种有效的选择性5-HT6受体激动剂,Ki 为 2.2 nM,EC50为 6.6 nM。它介导 5-HT6 受体依赖性信号通路,可作为特异性激动剂。 |