Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5382 |
Ritlecitinib
PF-06651600 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Ritlecitinib (PF-06651600) 是一种口服有效的选择性JAK3抑制剂,IC50值为 33.1 nM。 | |||
T5382L |
PF-06651600 malonate
PF 06651600,PF-06651600,PF06651600 |
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PF-06651600 is a potent and selective JAK3 inhibitor. | |||
T60565 |
(2R,5S)-Ritlecitinib
|
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(2R,5S)-Ritlecitinib (2R,5S)-PF-06651600) 是有效的选择性 JAK3抑制剂,IC50 值为144.8 nM。 | |||
T69822 |
Ritlecitinib tosylate
|
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Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this JAK3-specific inhibitor PF-06651600 led to its evaluation in several human clinical studies. JAK3 was among the first of the JAKs targeted for therapeutic intervention due to the strong validation provided by human SCID patients displaying JAK3 deficiencies. |