Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39207 |
L-803087 TFA
|
||
L-803087 TFA is a highly potent and selective agonist of the somatostatin sst4 receptor, exhibiting a Ki value of 0.7 nM. It displays a remarkable selectivity, being over 280-fold more preferential for the sst4 receptor compared to other somatostatin receptors. Furthermore, L-803087 TFA promotes AMPA-mediated synaptic responses in hippocampal preparations and enhances kainate-induced seizures in mice. | |||
T11800 |
L-803087
|
Somatostatin | GPCR/G Protein |
L-803087 是一种具有高效性和选择性的生长抑素 sst4 受体激动剂,对 sst4 的 Ki 值为 0.7 nM,比其他生长抑素受体的选择性高 280 倍以上。L-803087 在体外诱导 AMPA 介导的海马突触反应,在体内增加了海藻酸盐促使的小鼠癫痫发作。 |