Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0259 |
Atrasentan
A-147627,(+)-A 127722,阿曲生坦,ABT-627 |
Endothelin Receptor | GPCR/G Protein |
Atrasentan (ABT-627) 是内皮素受体 (endothelin receptor) 拮抗剂,能够抑制 ETA 的活性(IC50:0.0551 nM)。 | |||
TQ0270 |
Atrasentan hydrochloride
(+)-A 127722 hydrochloride,ABT-627 hydrochloride,盐酸阿曲生坦,A-147627 hydrochloride |
Endothelin Receptor | GPCR/G Protein |
Atrasentan hydrochloride (ABT-627 hydrochloride) 是内皮素 A 受体选择性拮抗剂,抑制内皮素 A 受体活性的IC50为 0.0551 nM。 | |||
T70198 | Atrasentan sodium | ||
Atrasentan, also known as ABT-627, is a orally available ETA receptor antagonist with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation. |