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Cat. No. | Product Name | Target | Signaling Pathways |
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T79282 |
Antibacterial agent 144
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Antibacterialagent 144(compound 8e)是一款效能超过氯霉素和阿莫西林的抗菌药物,专门针对具有多重耐药性的金黄色葡萄球菌。该化合物通过破坏细菌的细胞质膜和抑制生物膜形成来发挥作用。Antibacterialagent 144能与HSA紧密结合(Kd=13.2 μM),显示出卓越的杀菌活性。它还能与DNA相结合,形成超分子复合物,有效阻断DNA复制过程。 | |||
T83705 |
BING TFA
Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria |
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BING是一种来源于日本稻田鱼(O. laptipes)的抗菌肽,由液泡蛋白质分选相关蛋白13D样(Vps13D)衍生而来。对包括耐甲氧西林的金黄色葡萄球菌(MRSA; MICs = 4-64 µg/ml)在内的各种革兰氏阴性和革兰氏阳性细菌都有活性。与氨苄西林、阿莫西林和新霉素共同使用时,对抗铜绿假单胞菌(P. aeruginosa)表现出协同效应,并能抑制大肠杆菌(E. coli)对卡那霉素和氨苄西林的抗药性发展。在体内,BING提高了被鳗弧菌(E. tarda)感染的O. laptipes的生存率。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T1033 |
Monensin sodium salt
莫能菌素钠盐,Sodium Monensin,Monensin A sodium salt |
Sodium Channel; Antibacterial; Antibiotic | Membrane transporter/Ion channel; Microbiology/Virology |
Monensin sodium salt (Monensin A sodium salt) 是由肉桂链霉菌 分泌的抗生素。它是一种介导Na+/H+交换的离子载体。它引起细胞多泡体 (MVBs) 增大并调节外泌体的分泌。 | |||
T1033L |
Monensin
Elancoban,Rumensin,莫能菌素 |
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Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with deregulated Wnt signaling. | |||
T40383 |
Monensin B
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Monensin B is a polyketide compound derived from the bacterium Streptomyces cinnamonensis. Its production involves the fermentation of Streptomyces cinnamonensis, resulting in a mixture of Monensin A and Monensin B. The ratio of these two compounds depends on the concentrations of ethylmalonyl-CoA and methylmalonyl-CoA. |