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Search Results for " γ-linolenic acid "

14

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T41323	Dihomo-γ-Linolenic acid methyl ester	Others	Others
	Dihomo-γ-Linolenic acid methyl ester 是 Dihomo-γ-Linolenic acid 的甲酯形式，Dihomo-γ-Linolenic acid 具有抗炎和抗增殖作用。
T41235	γ-Linolenic acid ethyl ester
	γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) 是一种白三烯 B 受体 4(LTB4)的拮抗剂，具有潜在的抗炎作用。
T35417	α-Linolenic Acid (sodium salt)
	α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.
T38046	Cholesteryl Homo-γ-Linolenate
	Cholesteryl homo-γ-linolenate is a cholesterol ester. It accumulates in the adrenal gland of rabbits fed a diet high in linolenic acid. Levels of cholesteryl homo-γ-linolenate are decreased and positively correlate with cognitive decline in HIV-infected humans.
T37855	7-hydroxycoumarinyl-γ-Linolenate
	7-hydroxycoumarinyl-γ-Linolenate is a γ-linolenic acid ester of 7-hydroxycoumarin (umbelliferone) that behaves as a substrate for cPLA2. Hydrolysis of 7-hydroxycoumarinyl-γ-linolenate by phospholipase results in the release of the fluorescent compound 7-hydroxycoumarin which can be monitored spectrophotometrically (excitation at 335 nm, emission at 450 nm).
T37976	13(S)-HOTrE(γ)
	13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid. It is synthesized in human platelets, but its specific function is not known.
T37395	13(S)-HpOTrE(γ)
	13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.
T37233	(±)14(15)-EpEDE
	8,11,14-Eicosatrienoic acid, also known as dihomo-γ-linolenic acid , is a polyunsaturated fatty acid (PUFA) produced from γ-linolenic acid by the action of fatty acid elongases. It can be metabolized by the cyclooxygenase pathway to produce 1-series prostaglandins (PGs) (e.g., PGE1). (±)14(15)-EpEDE is an EpEDE acid formed from 8,11,14-eicosatrienoic acid. This monoepoxide can be generated from the PUFA, in vitro, by the action of a strong oxidizing agent. Alternatively, this compound may be pro...
T36773	12(S)-HETrE
	12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA). 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.
T37159	8(S)-HETrE
	8(S)-HETrE is a monohydroxy polyunsaturated fatty acid produced by rabbit neutrophil lipoxygenase when dihomo-γ-linolenic acid is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE .
T37400	15(S)-HETrE
	15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid . It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.
T37919	Prostaglandin F1α PGF1α,Prostaglandin F1α
	Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3]
T36099	Jacaric Acid
	Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conju...
T37257	13,14-dihydro-15-keto Prostaglandin D1 13,14-dihydro-15-keto Prostaglandin D1
	Prostaglandin D1 (PGD1) is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2. 13,14-dihydro-15-keto Prostaglandin D1 (13,14-dihydro-15-keto PGD1) is the theoretical metabolite of PGD1 via the 15-hydroxy PG dehydrogenase metabolic pathway. No biological studies for this compound have been repo...

化合物

Dihomo-γ-Linolenic acid methyl ester

Cat.No: T41323

Target: Others

γ-Linolenic acid ethyl ester

Cat.No: T41235

α-Linolenic Acid (sodium salt)

Cat.No: T35417

Cholesteryl Homo-γ-Linolenate

Cat.No: T38046

7-hydroxycoumarinyl-γ-Linolenate

Cat.No: T37855

13(S)-HOTrE(γ)

Cat.No: T37976

13(S)-HpOTrE(γ)

Cat.No: T37395

(±)14(15)-EpEDE

Cat.No: T37233

Cat.No: T36773

Cat.No: T37159

Cat.No: T37400

Prostaglandin F1α

Cat.No: T37919

Synonym: PGF1α,Prostaglandin F1α

Cat.No: T36099

13,14-dihydro-15-keto Prostaglandin D1

Cat.No: T37257

Synonym: 13,14-dihydro-15-keto Prostaglandin D1

Cat. No.	Product Name	Target	Signaling Pathways
T21504	γ-Linolenic Acid methyl ester Methyl gamma-linolenate,γ-亚麻酸甲酯	LTR	Immunology/Inflammation
	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) 是一种弱白三烯 B4 (LTB4) 受体拮抗剂。
TQ0262	Dihomo-γ-linolenic acid Diroleuton,顺式-8，11，14-二十烷三烯酸甲酯,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989	Others	Others
	Ro 12-1989 can be converted into prostaglandin E1 (PGE1). Ro 12-1989 competes with arachidonic acid for COX and lipoxygenase, inhibiting the production of arachidonic acid's eicosanoids.
T4868	gamma-Linolenic acid gamolenic acid,γ-Linolenic acid,γ-亚麻酸	Endogenous Metabolite	Metabolism
	gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6)，18 碳 (18C-) 多不饱和脂肪酸 (PUFA)，可以从人乳和植物种子油中提取。

天然产物

γ-Linolenic Acid methyl ester

Cat.No: T21504

Synonym: Methyl gamma-linolenate,γ-亚麻酸甲酯

Target: LTR

Dihomo-γ-linolenic acid

Cat.No: TQ0262

Synonym: Diroleuton,顺式-8，11，14-二十烷三烯酸甲酯,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989

Target: Others

gamma-Linolenic acid

Cat.No: T4868

Synonym: gamolenic acid,γ-Linolenic acid,γ-亚麻酸

Target: Endogenous Metabolite

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