Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T80697 |
β5i-IN-1
|
Proteasome | Proteases/Proteasome; Ubiquitination |
β5i-IN-1 是 β5i 选择性抑制剂,具有 8.463 nM 的 IC50 值。该化合物能够诱导 TNF-α 和 IL-6 的释放,同时影响 NF-κB 的转录活性,适用于特发性肺纤维化研究。 | |||
T82529 |
DPLG3
|
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DPLG3是一种免疫蛋白酶体β5i亚基的特异性抑制剂,其对小鼠i-20S的IC50值为9.4 nM,可应用于免疫疾病相关研究领域。 | |||
T37420 |
Ac-ANW-AMC
Ac-ANW-AMC,Ac-Ala-Asn-Trp-AMC |
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Ac-ANW-AMC is a fluorogenic substrate for the β5i/LMP7 subunit of the 20S immunoproteasome. [1] Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β5i/LMP7 subunit of the 20S immunoproteasome. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. Reference[1]. Winter, M.B., La Greca, F., Arastu-Kapur, S., et al. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. ... |