Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18662 |
(S,R,S)-AHPC-C2-PEG4-N3
VH032-C2-PEG4-N3 |
Others | Others |
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate combining the (S,R,S)-AHPC-based VHL ligand with a 4-unit polyethylene glycol (PEG) linker, employed in PROteolysis TAgeting Chimera (PROTAC) technology. This compound facilitates the creation of vRucaparib-TP4, a potent PARP1 degrader demonstrating a half-maximal degrading concentration (DC50) of 82 nM[1]. |