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Cat. No. Product Name Target Signaling Pathways
T35439 (E)-5-(2-Bromovinyl)uracil

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

化合物

(E)-5-(2-Bromovinyl)uracil
Cat.No: T35439
Synonym:
Target:
TargetMol Loading
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