Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats. L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively.
产品描述 | L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) forms, respectively. |
靶点活性 | nNOS:ki: 1.7 μM , eNOS:3.9 μM (ki), iNOS:3.9 μM (ki) |
体外活性 | L-NIO is a non-selective,potent and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. |
体内活性 | L-NIO ?causes focal cerebral ischemia in the adult rat brain. |
分子量 | 209.67 |
分子式 | C7H16ClN3O2 |
CAS No. | 159190-44-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (135.42 mM), Sonication is recommended.
H2O: 50 mg/mL (203.14 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 4.7694 mL | 23.847 mL | 47.694 mL | 119.235 mL |
5 mM | 0.9539 mL | 4.7694 mL | 9.5388 mL | 23.847 mL | |
10 mM | 0.4769 mL | 2.3847 mL | 4.7694 mL | 11.9235 mL | |
20 mM | 0.2385 mL | 1.1923 mL | 2.3847 mL | 5.9617 mL | |
50 mM | 0.0954 mL | 0.4769 mL | 0.9539 mL | 2.3847 mL | |
100 mM | 0.0477 mL | 0.2385 mL | 0.4769 mL | 1.1923 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
L-NIO dihydrochloride 159190-44-0 Immunology/Inflammation NOS L-NIO Dihydrochloride LNIO dihydrochloride L NIO dihydrochloride L-NIO Inhibitor inhibitor inhibit