Cat. No. | Product Name | Target | Signaling Pathways |
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T9214 |
ELOVL6-IN-1
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Others | Others |
ELOVL6-IN-1 是一种选择性 ELOVL6抑制剂,口服具有活性。它对丙二酰辅酶 a (Ki:994 nM) 和对棕榈酰辅酶 a 具有非竞争性抑制 ELOVL6 作用。它能够剂量依赖性的一种小鼠 ELOVL6(IC50:0.350 μM)。 | |||
T74038 |
Palmitoyl coenzyme A lithium
|
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Palmitoyl coenzyme A lithium,一种酰基-CoA 硫酯,通过肉碱穿梭系统转运至线粒体基质,参与β-氧化,亦作为鞘氨醇生物合成底物。 | |||
T78140 |
ELOVL6-IN-3
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Others | Others |
ELOVL6-IN-1是一种具有高效、口服生物活性和选择性的ELOVL6抑制剂。该化合物针对小鼠ELOVL6展现剂量依赖性抑制,IC50为0.350 μM,并且对丙二酰辅酶a(Ki=994 nM)具有非竞争性抑制ELOVL6的活性,以及对棕榈酰辅酶a同样显示非竞争性抑制作用。 | |||
T38214 |
1-Deoxysphingosine (m18:1(4E))
1-Deoxysphingosine (m18:1(4E)) |
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1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 Plasma levels of 1-deoxysphingosine (m18:1(4E)) are increased in patients with chronic idiopathic axonal neuropathy (CIAP) and diabetic distal symmetrical polyneuropathy (DSPN).3 |1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemica... | |||
T38284 |
C24 dihydro 1-Deoxyceramide (m18:0/24:0)
C24 dihydro 1-Deoxyceramide (m18:0/24:0) |
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C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 dihydro 1-Deoxyceramide (m18:0/24:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found in mouse brain, spinal cord, ... | |||
T38280 |
C22 dihydro 1-Deoxyceramide (m18:0/22:0)
C22 dihydro 1-Deoxyceramide (m18:0/22:0) |
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C22 dihydro 1-Deoxyceramide (m18:0/22:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C22 dihydro 1-Deoxyceramide (m18:0/22:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found as the most prevalent dihydro... |