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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2151	pBD-1	Antibacterial	Microbiology/Virology
	pBD-1 is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites with the contribution of mucosal and systemic host defenses in pigs.
TP2151L	pBD-1 TFA (206367-33-1 free base) pBD-1 TFA	Antibacterial	Microbiology/Virology
	pBD-1 TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs.
T76062	pBD-1 TFA
	pBD-1 TFA 是一种来源于猪组织的内源性组成型表达的抗菌肽 (AMP)，尤其在猪黏膜上皮部位表达。pBD-1 TFA 具有抗菌作用，并且有助于猪黏膜和系统宿主防御。
T71718	Plk1 PBD-IN-143
	Plk1 PBD-IN-143 is a novel Inhibitor of the Polo-Box Domain of Polo-like Kinase 1 (Plk1 PBD).
T18364	Tesirine MP-PEG8-VA-PABC-PBD Dimer	Others	Others
	MP-PEG8-VA-PABC-PBD Dimer is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication[1].
T16025	SGD-1910 MC-Val-Ala-PBD	Others	Others
	MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].
T77086	Mipasetamab uzoptirine
	Mipasetamab uzoptirine (ADCT-601) 是一种 AXL 靶向的抗体-活性分子偶联物(ADCs)。Mipasetamab uzoptirine 由人源化抗 AXL 抗体、可裂解连接子和有效的吡咯并苯二氮卓 (PBD) 二聚体细胞毒素 SG3199 组成。Mipasetamab uzoptirine 可用于癌症研究。
T17801	DBCO-PEG4-VA-PBD	Others	Others
	DBCO-PEG4-VA-PBD is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T74863	Anthramycin
	Anthramycin, 一种属于苯并二氮杂卓（PBD）家族的有效抗生素（antibiotic），展现出显著的抗肿瘤（antitumor）活性。在小鼠中枢神经系统中，它也能作为胆收缩素（cholecystokinin）的有效拮抗剂。
T73678	Antibiotic DC 81
	AntibioticDC 81（DC 81）是由链霉菌产生的一种抗肿瘤抗生素，属于吡咯[2,1-c][1,4]苯二氮平（PBD）类。作为一种有效的核酸合成抑制剂，AntibioticDC 81通过识别并与特定DNA序列结合，形成不稳定的共价加合物。

化合物

pBD-1

Cat.No: TP2151

Synonym:

Target: Antibacterial

pBD-1 TFA (206367-33-1 free base)

Cat.No: TP2151L

Synonym: pBD-1 TFA

Target: Antibacterial

Synonym: MP-PEG8-VA-PABC-PBD Dimer

Target: Others

SGD-1910

Cat.No: T16025

Synonym: MC-Val-Ala-PBD

Target: Others

Mipasetamab uzoptirine

Cat. No.	Product Name	Target	Signaling Pathways
T3947	Nonanoic acid pelargonic acid,Nonoic acid,壬酸	Others; Antibacterial	Microbiology/Virology; Others
	Nonanoic acid (Nonoic acid) 是一种天然存在的具有九个碳原子的饱和脂肪酸。它减少细菌易位，增强抗菌活性，并增加猪 β-防御素 1 (pBD-1) 和 pBD-2 的分泌。