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Cat. No. | Product Name | Target | Signaling Pathways |
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T63620 | LRRK2-IN-3 | ||
LRRK2-IN-3 是有效的、选择性的、口服具有活力的、能够透过血脑屏障的 LRRK2 抑制剂,在 hPBMCs 中的 IC50 值为 0.6 nM。LRRK2-IN-3 能够用于研究帕金森氏病。 | |||
T79749 | TLR7 agonist 14 | ||
TLR7 agonist14(compound 17b)作为一种TLR7激动剂,具有高效性,其EC50值为59 nM。在低纳摩尔级别浓度下,TLR7 agonist14能有效激活小鼠巨噬细胞以及hPBMC。 | |||
T79751 | TLR7 agonist 16 | ||
TLR7 agonist16 (compound 16d)为一种高效的TLR7激动剂,具有EC50值为59 nM。在低纳摩尔水平上,它可以有效激活小鼠巨噬细胞和hPBMC。 | |||
T79750 | TLR7 agonist 15 | ||
TLR7 agonist15(compound 16b)作为一种高效的TLR7激动剂,其EC50值为59 nM。在低纳摩尔浓度下,该化合物能够有效诱导小鼠巨噬细胞和hPBMC的激活。 | |||
T82515 |
E104
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E104(compound 1)为一种高效且选择性的TLR7激动剂,适用于ADC合成,以激发显著的抗癌活性。该化合物能够诱导小鼠巨噬细胞与hPBMC的活化。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S0265 |
Robinin
NSC 9222,刺槐素 |
TLR | Immunology/Inflammation |
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry. |