Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1170 |
Flagelin 22
Flagellin 22 |
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Flagelin 22, a bacterial flagellin fragment, serves as a potent elicitor for plants and algae. | |||
TP1169 |
Flagelin 22 TFA (304642-91-9 free base)
Flagellin 22 TFA,Flagelin 22 TFA |
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Flagelin 22 TFA (Flagellin 22 TFA), a fragment of bacterial flagellin, is an effective elicitor in both plants and algae. | |||
T8727 |
TH1020
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TLR; Antibacterial | Immunology/Inflammation; Microbiology/Virology |
TH1020 是一种选择性 Toll 样受体 5 /鞭毛蛋白复合拮抗剂,IC50为 0.85 μM。它抑制鞭毛蛋白诱导的TLR5信号传导。 | |||
TP1170L |
Flagelin 22 acetate
Flagelin 22 acetate(304642-91-9 free base) |
Others | Others |
Flagelin 22 acetate 是细菌鞭毛蛋白的一部分,是在植物和藻类中一种有效的诱导剂。 | |||
T37295 |
Ganglioside GM1 Asialo Mixture
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Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive na... | |||
T83852 |
EGFRvIII Peptide TFA
PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide |
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EGFRvIII peptide是一种合成肽,对应于特异性肿瘤、具有持续激活性的EGFR变体EGFRvIII的融合接头,该变体缺少野生型EGFR的第6至273个氨基酸。在25 µg/ml的浓度下,它能与MHC I类亚型HLA-A*0201阳性的T2细胞结合。在用于分离的人外周血单个核细胞(PBMCs)衍生的树突状细胞中,EGFRvIII peptide可诱导抗原呈递,进而刺激CD8+细胞毒性T淋巴细胞的激活和IFN-γ产生。与toll样受体5(TLR5)激动剂鞭毛蛋白B共同免疫EGFRvIII peptide(15 µg/动物),在正交GL261胶质母细胞瘤小鼠异种移植模型中,增加了CD8+ T细胞数量,减少了调节性T细胞(Tregs)数量,减少了肿瘤体积,并提高了生存率。 |