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Search Results for " fibrinolysis "

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0949	Tranexamic acid Amstat,Tranexamsaeure,氨甲环酸	Others	Others
	Tranexamic acid (Amstat) 是一种能阻断纤溶酶的赖氨酸结合位点和弹性蛋白酶来源的纤维蛋白溶酶原片段。
T28842	SQ-24,798 SQ 24,798,SQ24,798
	SQ-24,798 is an inhibitor of the thrombin-activatable fibrinolysis and carboxypeptidase N (CPN).
T70118	PSI-112
	PSI-112 is a fibrinolysis inhibitor.
T39551	S62798 S62798
	S62798 is a highly potent and selective compound that inhibits activated thrombin activatable fibrinolysis inhibitor (TAFIa) with an IC50 value of 6 mM.
T70652	SAR-104772
	SAR-104772 is a novel inhibitor of TAFIa (activated thrombin-activatable fibrinolysis inhibitor).
T71129	AZD6564
	AZD6564 is a fibrinolysis inhibitor which acts via interference of a protein-protein interaction.
T82286	Glycylglycylcysteine
	Glycylglycylcysteine是一种TAFI抑制剂，其Ki值0.99μM，IC50值为9.4μM，在TAFI底物测定中有效性得以体现。TAFI为一种碱性羧肽酶，通过裂解部分降解纤维蛋白末端的赖氨酸，起到抑制纤维蛋白溶解的功能。
T71851	5-trans-Prostaglandin E2
	5-trans-Prostaglandin E2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator. It also inhibits platelet aggregation in human PRP.
T11100	DS-1040 Tosylate	Others	Others
	DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa, is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM
T82526	Drotrecogin alfa (activated)
	Drotrecogin alfa activated (DrotAA)为重组人活化蛋白C（APC）。该化合物能够抑制由烟雾引起的大鼠肺微血管通透性上升及促炎细胞因子IL-1β水平增加，具有抗凝血与抗炎作用，并促进纤溶过程。Drotrecogin alfa activated主要用于重症脓毒症的实验研究。
T72113	6-Aminocaproic acid hydrochloride EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride
	6-Aminocaproic acid hydrochloride，一种单氨基羧酸，作为有效及口服活性的纤溶酶和纤溶酶原抑制剂，具备显著的抗纤溶能力。通过竞争性结合纤溶酶原上的赖氨酸残基，6-Aminocaproic acid hydrochloride 阻止血块溶解，抑制纤溶酶生成，减少纤维蛋白溶解，用于出血性疾病研究。

化合物

Tranexamic acid

Cat.No: T0949

Synonym: Amstat,Tranexamsaeure,氨甲环酸

Target: Others

SQ-24,798

Cat.No: T28842

Synonym: SQ 24,798,SQ24,798

5-trans-Prostaglandin E2

Drotrecogin alfa (activated)

Cat.No: T82526

Synonym:

Target:

6-Aminocaproic acid hydrochloride

Cat.No: T72113

Synonym: EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T0881	6-Aminocaproic acid 氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid	Others	Others
	6-Aminocaproic acid (EACA) 是一种单氨基羧酸，是一种有效的、具有口服活性的纤溶酶和纤溶酶原的抑制剂。它是一种有效的抗纤维蛋白溶解剂，能够竞争性结合纤溶酶原上的赖氨酸残基，防止血块溶解，并抑制纤溶酶的形成，减少纤维蛋白溶解。它可用于出血性疾病的研究。

天然产物

6-Aminocaproic acid

Cat.No: T0881

Synonym: 氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid

Target: Others

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