Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11170 |
eIF4A3-IN-1
|
Others | Others |
eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD. | |||
T72943 | eIF4A3-IN-17 | ||
eIF4A3-IN-17 是 silvestrol 类似物。eIF4A3-IN-17 干扰 eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的 EC50值分别为 0.9,15 和 1.8 nM。eIF4A3-IN-17 可用于人类肿瘤发病机制的研究。 | |||
T73001 |
eIF4A3-IN-9
|
||
eIF4A3-IN-9 是silvestrol 类似物。eIF4A3-IN-9 干扰eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 29,450 和 80 nM。eIF4A3-IN-9 可用于人类肿瘤发病机制的研究。 | |||
T72944 |
eIF4A3-IN-18
|
||
eIF4A3-IN-18 是silvestrol 类似物。eIF4A3-IN-18 干扰eIF4F 翻译复合体组装,对 myc-LUC,tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 0.8、35 和 2 nM。eIF4A3-IN-18 对 RMPI-8226 细胞具有细胞毒性,LC50值为 0.06 nM。eIF4A3-IN-18 可用于人类肿瘤发病机制的研究。 |