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10

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40732	TMPD dihydrochloride
	TMPD dihydrochloride 是酶促转化氧化还原的活性底物和用于还原血红素过氧化物酶的电子供体。
T76169	Angiotensin-converting enzyme
	Angiotensin-converting enzyme (ACE)血管紧张素转换酶是一种二羧基肽酶，它将非活性的血管紧张素 I (Ang I) 转化为活性的 Ang II，并降解活性的缓激肽 (BK)。Angiotensin-converting enzyme 是一种有效的血管收缩剂，常用于生化研究。
T31218	DBHDA
	DBHDA is a reagent to convert a Cys into a Dha moiety by reacting with a C-terminal Cys residue and thus allowing the use of recombinant Ubl G76C mutants to prepare probes.
T37227	(±)8(9)-DiHET
	Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
T36058	Dibutyl-3-Hydroxybutyl Phosphate
	Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP). Incubation of goldfish liver microsomes in the presence of NADPH has been shown to convert TBP into dibutyl-3-hydroxybutyl phosphate and dibutyl phosphate. Dibutyl-3-hydroxybutyl phosphate has also been produced during radiolysis of TBP.
T81233	S-(p-Nitrobenzyl)glutathione
	S-(p-Nitrobenzyl)glutathione 是一种竞争性谷胱甘肽酶(GGT)抑制剂，能被大鼠肾微粒体转化成相应的半胱氨酸衍生物。该化合物用于研究谷胱甘肽酶系统中GSH的代谢及其降解过程。
T70859	ent-Abacavir
	ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuroni...
T38351	DYn-2
	Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH). Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells. DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications. The a...
T69895	Lonaprisan
	Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; binding of this agent to PRs inhibits PR activation and the associated proliferative effects. Unlike many other antiprogestins such as mifepristone, this agent does not appear to convert to an agonist in the presence of protein kinase A (PKA) activators and shows high antiprogesta...
T38142	Phosphatidylethanolamines (soy)
	Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial m...

化合物

TMPD dihydrochloride

Cat.No: T40732

Angiotensin-converting enzyme

Cat.No: T76169

Cat.No: T31218

Cat.No: T37227

Dibutyl-3-Hydroxybutyl Phosphate

Cat.No: T36058

S-(p-Nitrobenzyl)glutathione

Cat.No: T81233

Cat.No: T70859

Cat.No: T38351

Cat.No: T69895

Phosphatidylethanolamines (soy)

Cat.No: T38142

Cat. No.	Product Name	Target	Signaling Pathways
T4931	Dihydroxyfumaric acid hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Dihydroxyfumaric acid hydrate 是内源性代谢产物的一种。
T9780	3,4, 5-trimethoxyphenylacetic acid	Endogenous Metabolite	Metabolism
	3,4, 5-trimethoxyphenylacetic acid 是有机合成中常见的中间体，其主要用途是将其羧基转化为相应的用途。
T4843	2,2-Dihydroxyacetic acid Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物	Others; Endogenous Metabolite	Metabolism; Others
	2,2-Dihydroxyacetic acid (Formylformic acid) 是乙醛酸循环的中间体，使某些生物体能够将脂肪酸转化为碳水化合物。2,2-Dihydroxyacetic acid 被发现与原发性高草酸尿有关，这是一种先天性代谢错误。作为一种醛，乙醛酸酯也具有高活性，可以修饰蛋白质形成晚期糖基化产物(AGEs)。

天然产物

Dihydroxyfumaric acid hydrate

Cat.No: T4931

Target: Others, Endogenous Metabolite

3,4, 5-trimethoxyphenylacetic acid

Cat.No: T9780

Target: Endogenous Metabolite

2,2-Dihydroxyacetic acid

Cat.No: T4843

Synonym: Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物

Target: Others, Endogenous Metabolite

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