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Cat. No. | Product Name | Target | Signaling Pathways |
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T21358 |
Dalbavancin
BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星 |
Antibacterial; Antibiotic | Microbiology/Virology |
Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素,对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg/mL 和 0.25 μg/mL。 | |||
T80277 |
CaLL
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CaLL为具抗菌活性的抗菌肽,针对B. anthracis, B. anthracis (vegetative), and B. cepacia表现出MIC为7.8、31.3、31.3 μg/mL的效力。 | |||
T80372 |
P1
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P1是一种具有抗革兰氏阳性菌与抗革兰氏阴性菌能力的广谱抗菌肽,有效针对B. anthracis、耐碳青霉烯类细菌A. baumannii和K. pneumoniae。 | |||
T78310 |
Raxibacumab
ABthrax |
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Raxibacumab (ABthrax)是针对炭疽杆菌(Bacillus anthracis)保护性抗原(PA)的人类IgG1型单克隆抗体。该抗体能够防止保护性抗原与宿主细胞受体结合,有效阻断炭疽毒素的有毒效应,用于炭疽病防治研究。 | |||
T72002 | Carbazomycin C | ||
Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus, the fungi T. asteroides and T. mentagrophytes, and P. falciparum. It is also active against a panel of five plant pathogenic fungi. Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts. | |||
T75253 | Dalbavancin hydrochloride | ||
Dalbavancin hydrochloride (MDL-63397 hydrochloride)为半合成脂糖肽类抗生素,有效对抗革兰氏阳性菌。其对金黄色葡萄球菌与炭疽芽孢杆菌的MIC90分别为0.06 μg/mL与0.25 μg/mL。 | |||
T36748 |
Heliquinomycin
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Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus(MICs = <0.05-0.39 μg/ml). Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 μM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 μg/ml, resp... | |||
T83843 |
2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium
2'(3')-ANT-GTP |
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2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate(2'-ANT-GTP)及3'-ANT-GTP是荧光GTP衍生物,能够自发进行异构化。2'(3')-ANT-GTP在水中的激发波长为330 nm时,发射最大波长为428 nm。它抑制哺乳动物腺苷酸环化酶1(AC1;在锰存在下Ki=10 nM)、B. anthracis AC毒素水肿因子(在锰和镁存在下Kis分别为4.1 和 13 µM)及B. pertussis AC毒素CyaA(在锰存在下Ki=29 µM)。 | |||
T83811 |
2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium
2'(3')-ANT-ATP |
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2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate(2'-ANT-ATP)与3'-ANT-ATP是荧光ATP衍生物,可自发地进行异构化。在水中,2'(3')-ANT-ATP的激发波长为330 nm时,发射最大波长为428 nm。它对哺乳动物腺苷酸环化酶(AC1)、AC2及AC5显示出抑制作用,抑制常数(Kis)分别为130、640和120 nM。此外,它还能抑制百日咳杆菌腺苷酸环化酶毒素CyaA(在锰和镁存在下,Kis分别为1.3和20 µM)、炭疽杆菌腺苷酸环化酶毒素水肿因子(在锰和镁存在下,Kis分别为0.44和5.15 µM)以及大肠杆菌重组酶A(RecA;Ki = 6.3 µM)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN7094 |
Coreoside B
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Antibacterial | Microbiology/Virology |
Coreoside B 是从coreoside 中分离出来的,对金黄色葡萄球菌和炭疽杆菌显示出较弱的抗菌活性。 | |||
T8211 |
(±)-Decursinol
紫花前胡醇,3',4'-dihydro-3'-hydroxy-Xanthyletin |
Others; Antibacterial | Microbiology/Virology; Others |
(±)-Decursinol (3',4'-dihydro-3'-hydroxy-Xanthyletin) 是来自当归的一种 FtsZ 抑制剂,抑制 B. anthracis 的 FtsZ 聚合,IC50为 102 μM。 | |||
T83918 |
Clazamycin A hydrochloride
NSC 332188 |
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Clazamycin A是一种最初从链霉菌中分离出的抗生素和微生物代谢产物。它对多种细菌具有活性,包括S. aureus、B. anthracis、B. subtilis、E. coli和P. aeruginosa(MICs分别为100、6.25、100、50和25 µg/ml)。 | |||
T83862 |
Bactobolin A hydrochloride
BN-183B |
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Bactobolin A 是一种最初从 Pseudomonas 中分离出的微生物代谢产物,具有抗生素和抗癌活性。它对 S. aureus、S. epidermidis、S. faecalis、B. anthracis、B. subtilis、E. coli、S. typhi 和 S. dysenteriae 活跃(MICs = 0.1-12.5 µg/ml)。在体内,bactobolin A (0.25-4 mg/kg) 提高了 L1210 小鼠白血病模型的存活率。 | |||
T35667 |
Napyradiomycin A1
Napyradiomycin A1 |
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Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM... |