Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23548 |
YM-298198 hydrochloride
YM 298198 hydrochloride |
Others | Others |
mGlu1 receptor antagonist | |||
T71764 |
YM 298198 Hydrochloride
|
Others | Others |
YM 298198 Hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM). YM 298198 Hydrochloride is inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 > 10 μM). It inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 μM respectively). |