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Cat. No. Product Name Species Expression System
TMPK-00732 WISP1/CCN4 Protein, Mouse, Recombinant (His)

ELM-1,WISP1tc,WISP1<...

Mouse HEK293 Cells
The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.
TMPY-00950 WISP1/CCN4 Protein, Human, Recombinant (His)

WISP1c,WISP1i,CCN4,WNT

Human HEK293 Cells
CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ...

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WISP1/CCN4 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-00732
Species: Mouse
Expression System: HEK293 Cells
WISP1/CCN4 Protein, Human, Recombinant (His)
Cat.No: TMPY-00950
Species: Human
Expression System: HEK293 Cells
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