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Cat. No.	Product Name	Target	Signaling Pathways
T69712	Icapamespib HCl	Others	Others
	Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans.
T38391	Icapamespib PU-HZ151,Icapamespib	Others	Others
	Icapamespib (PU-HZ151), a potent HSP90 inhibitor, exhibits an EC50 of 5 nM and possesses the capability to cross the blood-brain barrier.