Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40255 |
VCP/p97 inhibitor-1
VCP/p97 inhibitor-1 |
||
VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS). | |||
T12236 |
NMS-859
ZINC169324353 |
Others | Others |
NMS-859 是一种有效的含 valosin 蛋白 (VCP)/p97 的共价抑制剂,在细胞中存在 60 μM 和 1 mM ATP 的情况下,对野生型 VCP 的 IC50 分别为 0.37 μM 和 0.36 μM。 |