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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T76865 Enavatuzumab

Enavatuzumab (PDL192; ABT-361)为一种人源化IgG1单克隆抗体,专门靶向TNF样细胞凋亡弱诱导剂受体(TWEAK)。TWEAK是TWEAK受体(TweakR)的自然配体,能激活多种细胞反应。Enavatuzumab通过激活TweakR信号和促进抗体依赖性细胞介导的细胞毒性(ADCC),有效抑制肿瘤生长,并能招募骨髓效应细胞,进而消灭肿瘤细胞。该药物已在体外及体内实验中证实,能够抑制多种TweakR阳性的人类癌细胞系与异种移植瘤的增长。

化合物

Enavatuzumab
Cat.No: T76865
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-02757 TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc)

FN14,CD266,TWEAKR,tumor necrosis factor receptor su...

Human HEK293 Cells
Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Fn14 shares 82% amino acid identity with the mouse sequence. It contains a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic domain. In response to FGF1, calf serum, or phorbol ester stimulation of human quiescent fibroblasts in vitro, the level of Fn14 is increased. A 1.2-kb FN14 transcript was expressed at high levels in heart, placent...
TMPJ-01312 TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc)

Fibroblast growth factor-regulated protein 2,TNFRSF12,Tumor ...

Mouse HEK293 Cells
Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inf...

重组蛋白

TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02757
Species: Human
Expression System: HEK293 Cells
TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-01312
Species: Mouse
Expression System: HEK293 Cells
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