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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62095 | TRK-IN-19 | ||
TRK-IN-19 (Compound I-10 ) 是一种 TRK 的有效抑制剂,对 TRKA、TRKAG595R 的 IC50 值分别为 1.1 nM、5.3 nM。TRK-IN-19 对癌症疾病表现出潜在的研究价值。 | |||
T61443 | Trk-IN-7 | ||
Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (IC50 <15 nM), as well as ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50 = 5-50 nM) [1]. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00774 |
TrkA Protein, Human, Recombinant (aa 33-417, His)
TrkAI,TrkA I,Trk-A,T... |
Human | HEK293 Cells |
TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signaling pathways, resulting in diverse biological effects. |