Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17131 |
Tos-PEG4-CH2-Boc
|
Others | Others |
Tos-PEG4-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14721 |
Boc-Aminooxy-PEG4-Tos
|
Others | Others |
Boc-Aminooxy-PEG4-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17119 | Tos-aminoxy-Boc-PEG4-Tos | Others | Others |
Tos-aminoxy-Boc-PEG4-Tos is a PEG4-based PROTAC linker utilized for the synthesis of PROTACs[1]. | |||
T18464 |
N-(Tos-PEG4)-N-bis(PEG4-Boc)
|
Others | Others |
N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1]. | |||
T18628 |
Tos-PEG4-NH-Boc
PROTAC Linker 7 |
Others | Others |
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based linker used for the synthesis of PROTACs[1]. | |||
T17133 |
Tos-PEG4-t-butyl ester
Tos-PEG4-Boc |
Others | Others |
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition. This compound plays a crucial role in the synthesis of a range of PROTACs, including BI-3663, a highly selective PTK2/FAK PROTAC. It employs cereblon ligands to target E3 ligases for the degradation of PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1]. |