Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18614 |
Bis-Tos-PEG4
Tetraethylene glycol di(p-toluenesulfonate),PROTAC Linker 16,1,11-Bis(tosyloxy)-3,6,9-trioxaundecane |
Others; PROTAC Linker | Others; PROTAC |
Bis-Tos-PEG4 (PROTAC Linker 16) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T15886 |
m-PEG4-Tos
|
Others | Others |
m-PEG4-Tos, a PEG-based PROTAC linker derived from silybin ethers, finds application in the synthesis of Silymarin[1]. | |||
T17132 |
Tos-PEG4-CH2COOH
|
Others | Others |
Tos-PEG4-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17126 |
Tos-PEG4-acid
|
Others | Others |
Tos-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18853 |
Tos-PEG4-THP
|
Others | Others |
Tos-PEG4-THP is a polyethylene glycol (PEG) derivative utilized as a linker in the synthesis of PROTAC K-Ras Degrader-1, a potential therapeutic compound for targeted degradation of K-Ras protein [1]. | |||
T17119 | Tos-aminoxy-Boc-PEG4-Tos | Others | Others |
Tos-aminoxy-Boc-PEG4-Tos is a PEG4-based PROTAC linker utilized for the synthesis of PROTACs[1]. | |||
T17131 |
Tos-PEG4-CH2-Boc
|
Others | Others |
Tos-PEG4-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14721 |
Boc-Aminooxy-PEG4-Tos
|
Others | Others |
Boc-Aminooxy-PEG4-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T16635 | Propargyl-PEG4-Tos | Others | Others |
Propargyl-PEG4-Tos is a PEG-based PROTAC linker utilized for the synthesis of PROTACs and cleavable ADC linkers in antibody-drug conjugate (ADC) synthesis [1][2]. | |||
T14395 |
Azide-PEG4-Tos
|
Others | Others |
Azide-PEG4-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18464 |
N-(Tos-PEG4)-N-bis(PEG4-Boc)
|
Others | Others |
N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1]. | |||
T17133 |
Tos-PEG4-t-butyl ester
Tos-PEG4-Boc |
Others | Others |
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition. This compound plays a crucial role in the synthesis of a range of PROTACs, including BI-3663, a highly selective PTK2/FAK PROTAC. It employs cereblon ligands to target E3 ligases for the degradation of PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1]. | |||
T13989 |
1,1,1-Trifluoroethyl-PEG4-Tos
|
Others | Others |
1,1,1-Trifluoroethyl-PEG4-Tos is a polyethylene glycol (PEG) derived linker molecule which offers utility in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1]. | |||
T18628 |
Tos-PEG4-NH-Boc
PROTAC Linker 7 |
Others | Others |
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based linker used for the synthesis of PROTACs[1]. | |||
T17055 |
Tetraethylene glycol monotosylate
Tos-PEG4 |
Others | Others |
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |