Cat. No. | Product Name | Target | Signaling Pathways |
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T63594 |
Topoisomerase IIα-IN-3
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Topoisomerase IIα-IN-3 是 DNA 插入型 topoisomerase-Iiα 抑制剂,能够将细胞周期阻滞在 G0/G1 期,并诱导细胞凋亡 (apoptosis)。 | |||
T36695 |
TAS-103
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TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ... |