Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13930 |
TL13-12
|
Others; PROTACs | Others; PROTAC |
TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM). | |||
T37084 |
TL13-22
TL 13-22 |
||
Negative control for TL 13-12 . Displays no degradation of ALK in cell lines. Highly potent inhibitor of ALK (IC50 = 0.54 nM) Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID:29660984 |