Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62366 | TH-6 | ||
TH-6 是一种 HDAC 的有效抑制剂,能够作用于 HDAC1 (IC50: 0.115 μM)、HDAC2 (IC50: 0.135 μM)、HDAC3 (IC50: 0.242 μM)、HDAC6 (IC50: 0.138 μM)、HDAC8 (IC50: 2.120 μM)。TH-6 能够将细胞周期阻滞在 G2/M 期,诱导细胞凋亡。TH-6 对细胞迁移和侵袭具有抑制作用,表现出抗肿瘤作用。 | |||
T70151 |
MeTC7
|
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MeTC7 is a VDR antagonist, which can be synthesized from 7-dehydrocholesterol (6) in two steps, inhibits VDR selectively, suppresses the viability of cancer cell-lines, and reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo. |