Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2110 |
TAT-Gap19
|
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Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19. Active in vivo. Brain penet | |||
TP2110L |
TAT-Gap19 acetate
|
Gap Junction Protein | Cytoskeletal Signaling |
TAT-Gap19 acetate 是 connexin43 hemichannel (Cx43 HC) 的特异性抑制剂。 它穿过血脑屏障并减轻小鼠的肝纤维化。它不抑制相应的 Cx43 GJC。 | |||
T41204 |
TAT-Gap19(I130A)
TAT-Gap19(I130A) |
||
TAT-Gap19(I130A) is a control peptide for TAT-Gap19, a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable. | |||
T75821 |
TAT-Gap19 TFA
|
||
TAT-Gap19 TFA为Cx模拟肽,特异性抑制connexin43半通道(Cx43 HC),但不影响相应的Cx43 GJC。该化合物具备透过血脑屏障功能,能够减轻小鼠肝纤维化。 |