Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7200 |
TAK-960
|
PLK | Cell Cycle/Checkpoint |
TAK-960 是选择性的 polo 样激酶 1 口服有效抑制剂,IC50为 0.8 nM,对 PLK2 和 PLK3 也有抑制作用,IC50分别为 16.9 和 50.2 nM。它抑制多种肿瘤细胞系的增殖,可治疗多种肿瘤异种移植。 | |||
T39553 |
TAK-960 monohydrochloride
|
||
TAK-960 monohydrochloride is an orally available compound that selectively inhibits polo-like kinase 1 (PLK1) with an IC 50 of 0.8 nM. It also demonstrates inhibitory activity against PLK2 (IC 50 of 16.9 nM) and PLK3 (IC 50 of 50.2 nM). Moreover, TAK-960 monohydrochloride effectively suppresses the proliferation of various cancer cell lines and exhibits significant efficacy against multiple tumor xenografts. |