Cat. No. | Product Name | Target | Signaling Pathways |
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T40365 | T-2513 | ||
T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA replication and RNA synthesis, ultimately resulting in cellular apoptosis. | |||
T63225 |
T-2513 hydrochloride
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T-2513 hydrochloride 是拓扑异构酶 I (topoisomerase I) 的选择性抑制剂。T-2513 hydrochloride 能够共价结合拓扑异构酶 I-DNA 复合物,保持其稳定性,并能够抑制 DNA 复制和 RNA 合成,导致细胞死亡。 | |||
T27141 |
Delimotecan
MEN4901,MEN 4901,T-0128,MEN-4901,T 0128 |
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Delimotecan is a DNA topoisomerase I inhibitor. Delimotecan had a long terminal half-life of 109 h, and relatively high exposures to T-2513 and SN-38 were obtained. The percentage decrease in WBC and absolute neutrophil count significantly correlated with |